60 Significant studies of abortion/prematurity risk 
                                      September 2005
 Prof. Barbara Luke exposes 'Preemie' risk

Sixty (60) Studies that showed a statistically significant increase
in Preterm Birth or Low Birth Weight after Surgical Induced Abortion;
the list starts below at 'List of 60 Significant APB Studies'

A. The 60 studies are at least 95% confident of increased
   risk of preterm birth or 'surrogates' for PTB (such as
   low birth weight or 2nd trimester spontaneous abortion)
   from previous surgical induced abortions (SIAs); this
   list, in all probability, is NOT a complete list of all
   such studies; studies preceded by "+" found that the more
   the number of prior abortions, the higher the preterm birth
   risk (studies 8,9,11,25,29,32,34,35,39,40,42,44,48,49,50,51,52,

B. All three studies that examined whether prior SIAs boosted
   the risk of subsequent XPBs (eXtremely Preterm Births) found
   that they did:

   1. Lumley J (Australia, 1993, study number 44)
   2. Lumley J (Australia, 1998, study number 49)
   3. Moreau C et al. (France, 2005, study number 59)
      [The 2005 'Moreau' study is the first European confirmation
      of the Australian XPB results of Judith Lumley]

C. These 60 studies involve 23 countries


List of 60 Significant APB Studies


 1 Barsy G, Sarkany J.  Impact of induced abortion on the birth
   rate and infant mortality. Demografia 1963;6:427-467

 2 Miltenyi K. On the effects of induced abortion. Demografia

 3 Furusawa Y, Koya Y. The Influence of artificial abortion
   on delivery. In: Koya Y, ed. Harmful effects of induced
   abortion.  Tokyo: Family Planning Federation of Japan,


 4 Drac P, Nekvasilova Z. Premature termination of pregnancy
   after previous interruption of pregnancy. Cesk Gynekol

 5 Pantelakis SN, Papadimitriou GC, Doxiadis SA.
   Influence of induced and spontaneous abortions
   on the outcome of subsequent pregnancies. Amer
   J Obstet Gynecol. 1973;116:799-805

 6 Van Der Slikke JW, Treffers PE. Influence of
   induced abortion on gestational  duration in
   subsequent pregnancies. BMJ 1978;1:270-272
   [>95% confident of preterm risk for gestation
   less than 32 weeks]

 7 Richardson JA, Dixon G. Effect of legal termin-
   ation on subsequent pregnancy. British Med J

+8 Papaevangelou G, Vrettos AS, Papadatos D, Alexiou
   C. The Effect of Spontaneous and Induced Abortion
   on Prematurity and Birthweight. The J Obstetrics
   and Gynaecology of the British Commonwealth. May

+9 Bognar Z, Czeizel A.  Mortality  and  Morbidity
   Associated with Legal Abortions in Hungary, 1960-
   1973. AJPH 1976;66:568-575

10 Grindel B, Lubinski H, Voigt M. Induced abortion
   in primigravidae and subsequent pregnancy, with
   particular attention of underweight. Zentralbl
   Gynaekol 1979;101:1009-1114

+11 Obel E, et al. Pregnancy Complications Following
   Legally Induced Abortion With Special Reference to
   Abortion Technique. Acta Obstet Gynecol Scand

12 World Health Organization Task Force on the Sequelae
   of Abortion. Gestation, birthweight and spontaneous
   abortion. Lancet 1979;1:142-145.

13 Ratter G et al. Effect of Abortion on Maturity of
   Subsequent Pregnancy. Med J Australia June 1979:

14 Roht LH, Aoyama H, Leinen GE, et al. The association
   of multiple induced abortions with subsequent
   prematurity and spontaneous abortion. Acta Obstet
   Gynaecol Jpn 1976;23:140-145

15 Harlap S, Davies AM. Late sequelae of induced abortion:
   Complications and Outcome of Pregnancy and Labor. Amer
   J Epidemiology  1975;102:219-224

16 Mocsary P, Csapo AI. Effect of menstrual induction on
   prematurity rate. Lancet 1978;1:1159-1160

17 Koller O, Eikhom SN. Late Sequelae of Induced
   Abortion in Primigravidae. Acta Obstet Gynecol
   Scand 1977;56:311-317

18 Lean TH, Hogue CJR, Wood J. Low birth weight after induced
   abortion in Singapore, Presented at the 105th Annual Meeting
   of the Americal Public Health Association, Washington DC,
   Oct. 31, 1977

19 World Health Organization. Special Programme of Research,
   Development and Research Training in Human Reproduction:
   Seventh Annual Report, Geneva, Nov. 1978.

20 Hungarian Central Statistical Office. Perinatalishalazons.
   Budapest: Hungarian Central Statistical Office, 1972

21 Czeizel A, Bognar Z, Tusnady G, et al. Changes in mean birth
   weight and proportion of low-weight births in Hungary. Br J
   Prev Soc Med  1970;24:146-153

22 Dziewulska W.  Abortion in the past versus the fate of the
   subsequent pregnancy.  State of the newborn.  Ginekol Pol
   1973;44:1143-1148 [Poland]


23 Zwahr C, Voigt M, Kunz L, et al. Relationships
   between interruption abortion, and premature birth
   and low birth weight. Zentrabl Gynaekol 1980;102:

24 Kreibich H, Ludwig A. Early and late complications
   of abortion in juvenile primigravidae (including
   recommended measures). Z Aerztl Fortbild (Jena)

+25 Levin A, Schoenbaum S, Monson R, Stubblefield P,
   Ryan K. Association of Abortion With Subsequent
   Pregnancy Loss. JAMA 1980;243(24):2495-2499

26 Legrillo V. Quickenton P, Therriault GD, et al.
   Effect of induced abortion on subsequent reproductive
   function. Final report to NICHD. Albany, NY: New
   York State Health Department, 1980.

27 Slater PE, Davies AM, Harlap S. The Effect of Abortion Method
   on the Outcome of Subsequent Pregnancy. J Reprod Med 1981;28:

28 Lerner RC, Varma AO. Prospective study of the outcome of
   pregnancy subsequent to previous induced abortion. Final
   report, Contract no. (N01-HD-62803). New York: Downstate
   Medical Center, SUNY, January 1981.

+29 Berkowitz GS. An Epidemiologic Study of Preterm
   Delivery. American J Epidemiology 1981;113:81-92

30 Meirik O, Bergstrom R. Outcome of delivery subsequent to
   vacuum aspiration abortion in nulliparous women.  Acta
   Obstet Gynecol Scand 1982;61:415-429

31 Schoenbaum LS, Monson RR. No association between
   coffee consumption and adverse outcomes of pregnancy.
   NEJM 1982;306:141-145

+32 Puyenbroek J, Stolte L. The relationship between spontaneous
   and induced abortions and the occurrence of second-trimester
   abortion in subsequent pregnancies. Eur J Obstet Gynecol
   Reprod Biol  1983;14:299-309 [this is the only study in
   this complete list that uses second-trimester miscarriage
   as a surrogate for PTB]

33 Pickering RM, Forbes J. Risk of preterm delivery
   and small-for-gestational age infants following
   abortion: a population study. British J Obstetrics
   and Gynecology 1985;92:1106-1112

+34 Lumley J. Very low birth-weight (less than 1500g) and previous
   induced abortion: Victoria 1982-1983. Aust NZ J Obstet Gynecol

+35 Shiono PH, Lebanoff MA.  Ethnic  Differences
   and  Very Preterm Delivery. Am J Public Health

36 Lieberman E, Ryan KJ, Monson RR, Schoenbaum SC.
   Risk Factors Accounting For Racial Differences
   in the rate of premature birth. NEJM 1987;317:

37 Krasomski G, Gladysiak A, Krajewski J.  [English translation of
   Polish title: Fate of subsequent pregnancies after induced abortion
   in primiparae].  Wiad Lek. 1987 Dec 1;40(23):1593-1995

38 Seidman DS, Ever-Hadani P, Slater PE, Harlap S, et al.
   Child-bearing after induced abortion: reassessment of
   risk. J Epidemiology Community Health 1988;42:294-298

+39 Mueller-Heubach E, Guzick DS. Evaluation of
   risk scoring in a preterm birth prevention
   study of indigent patients. Am J Obstetrics
   & Gyn  1989;160:829-837


+40 Vasso L-K, Chryssa T-B, Golding J. Previous
   obstetric history and subsequent preterm delivery
   in Greece. European J Obstetrics & Gynecology
   Reproductive Biology   1990;37:99-109

41 Pickering RM, Deeks JJ. Risks of Delivery during
   20th to the 36th Week of Gestation. Intl. J
   Epidemiology 1991;20:456-466

+42*Zhang J, Savitz DA. Preterm Birth Subtypes among Blacks and
   Whites. Epidemiology 1992;3:428-433

43*Michielutte R, Ernest JM, Moore ML, Meis PJ,
   Sharp PC, Wells HB, Buescher PA. A Comparison of
   Risk Assessment Models for Term and Preterm Low
   Birthweight. Preventive Medicine 1992;21:98-109

+44 Lumley J. The epidemiology of preterm birth.
   Bailliere's Clin Obstet Gynecology. 1993;7(3):477-498

45 Guinn D, Goldenberg RL, Hauth JC, Andrews WA et al. Risk factors
   for the development of preterm premature rupture of membranes
   after arrest of preterm labor.  AJOG 1995;173(4):1310-1315

46*Hillier SL, Nugent RP, Eschenbach DA, Krohn MA,
   et al. Association Between Bacterial Vaginosis
   And Preterm Delivery Of A Low-Birth-Weight
   Infant. NEJM 1995;333:1737-1742

47 Khalil AK, El-Amrawy SM, Ibrahim AG, et al. Pattern of growth
   and development of premature children at the age of two and
   three years in Alexandria, Egypt.  Eastern Mediterranean Health
   Journal  1995;1(2):186-193

+48 Lang JM, Lieberman E, Cohen A.  A  Comparison
   of Risk Factors for Preterm Labor and Term
   Small-for-Gestational-Age Birth. Epidemiology

+49 Lumley J. The association between prior spon-
   taneous abortion, prior induced abortion and
   preterm birth in first singleton births.
   Prenat Neonat Med 1998;3:21-24.

+50 Martius JA, Steck T, Oehler MK, Wulf K-H. Risk
   factors associated with preterm (<37+0 weeks) and
   early preterm (<32+0 weeks): univariate and multi-
   variate analysis of 106 345 singleton births from
   1994 statewide perinatal survey of Bavaria.
   European J Obstetrics & Gynecology Reproductive
   Biology 1998;80:183-189

+51*Ancel P-V, Saurel-Cubizolles M-J, Renzo GCD,
   Papiernik E, Breart G. Very and moderate preterm
   births: are the risk factors different? British
   J Obstetrics and Gynaecology 1999;106:1162-1170

+52 Zhou W, Sorenson HT, Olsen J. Induced Abortion
   and Subsequent Pregnancy Duration. Obstetrics &
   Gynecology 1999;94:948-953

53 Ancel PY, Saurel-Cubizolles, Di Renzo GC, Papiernik E, Breart G.
   Social Differences of very preterm birth in Europe: interaction
   with obstetric history.  American J Epi 1999;149(10):908-915


54 Foix-L'Helias and Blondel B.  Changes in risk factors of
   preterm delivery in France between 1981 and 1995.  Paediatric
   and Perinatal Epidemiology.  Oct 2000;14(4):314-323

+55 Henriet L, Kaminski M. Impact of induced abortions on
   subsequent pregnancy outcome: the 1995 French national
   perinatal survey. British J Obstetrics Gynaecology

56 Grimmer I, Buhrer C, Dudenhausen JW.  Preconceptional factors
   associated with very low birth weight delivery: a case control
   study.  BMC Public Health 2002;2:10  [Germany]

57 Reime B, Schuecking BA, Wenzlaff P.  Perinatal outcomes of
   teenage pregnancies according to gravidity and obstetric history.
   Annals of Epidemiology 2004;14(8):619-619  [German subjects]

+58 Ancel PV, Lelong N, Papiernik E, Saurel-Cubizolles MJ, Kaminski M.
   History of induced abortion as a risk factor for preterm birth in
   European countries: results of EUROPOP survey. Human Repro 2004;
   19(3): 734-740.

+59 Moreau C, Kaminski M, Ancel PY, Bouyer J, et al. Previous induced
   abortions and the risk of very preterm delivery: results of the
   EPIPAGE study. British J Obstetrics Gynaecology 2005;112(4):430-437
   [France] [abstract online:
            j.1471-0528.2004.00478.x/abs/   ]

60 Conde-Agudelo A, Belizan JM, Breman R, Brockman SC, Rosas-
   Bermudez.  Effect of the interpregnancy interval after an
   abortion on maternal and perinatal health in Latin America.
   Int J Gynaecol & Obstet   2005;89 (Supp. 1):S34-S40


*  studies that included spontaneous and induced
   abortions but did not report PTB/LBW risk separately for each
+  studies that found dose/response (the more SIAs, the higher the risk)

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